Features of Maternal HIV-1 Associated with Lack of Vertical Transmission

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Features of Maternal HIV-1 Associated with Lack of Vertical Transmission

HIV-1 is transmitted from mother-to-child (vertical transmission) at an estimated rate of approximately 30% without any antiretroviral therapy (ART). However, administration of ART during pregnancy considerably diminishes the rate of mother-to-child transmission of HIV-1, which has become a standard of perinatal care in HIV-infected pregnant females in developed countries. Moreover, a majority ...

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Evaluation of factors associated with vertical HIV-1 transmission.

OBJECTIVE To compare the prevalence and factors associated with vertical transmission of human immunodeficiency virus 1 (HIV-1) among pregnant women treated in the periods of 1998-2004 and 2005-2011 in a reference service for the care of HIV-infected patients in southern Brazil. METHODS This was a descriptive and analytical study that used the databases of laboratories from the CD4 and STDs/A...

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Maternal and Perinatal Risk Factors Associated with Vertical Transmission of Hiv-1 Infection from Mother to Child

In 2009, the US Centers for Disease Control and Prevention (CDC) estimated that almost 11,000 children younger than 13 years old in the United States were diagnosed with HIV infection. Of those, it is estimated that the vast majority (88%) acquired the HIV infection perinatally. Given that both perinatal transmission is the most common route of HIV infection in children under 13 in the US and t...

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Maternal HIV infection and vertical transmission of pathogenic bacteria.

BACKGROUND HIV-exposed newborns may be at higher risk of sepsis because of immune system aberrations, impaired maternal antibody transfer and altered exposure to pathogenic bacteria. METHODS We performed a secondary analysis of a study (clinicaltrials.gov, number NCT00136370) conducted between April 2004 and October 2007 in South Africa. We used propensity score matching to evaluate the assoc...

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Vertical Transmission of HIV-1. Correlation with maternal viral load and plasma levels of CD4 binding site anti-gp120 antibodies.

Almost all childhood HIV-1 is now acquired through vertical transmission. Identifying factors that affect the rate of transmission may lead to the initiation of specific preventive strategies. In this study, antibody levels against different neutralizing epitopes on the envelope glycoprotein of HIV-1 (gp120) were measured in HIV-1-infected pregnant women that either transmitted HIV-1 to their i...

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ژورنال

عنوان ژورنال: The Open Virology Journal

سال: 2017

ISSN: 1874-3579

DOI: 10.2174/1874357901710011008